SOLVED:The mitogen-activated protein (MAP) kinase cascade triggered by R T Ks results in cell division. Create a few possible scenarios of abnormalities in the M A P K pathway leading to uncontrolled cell proliferation. a. gain of function mutation in R A S protein, mutation in I ? -B, loss of function mutation in genes for M A P K kinase pathway, regulated phosphorylation cascade b. loss of function mutation in R A S protein and gain of function mutation in RAF protein, I ? -B permanently bound

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SOLVED:Protein phosphorylation is commonly involved with all of the following except (A) activation of receptor tyrosine kinases. (B) activation of protein kinase molecules. (C) activation of G protein-coupled receptors. (D) regulation of transcription by signaling molecules.