Is Lithium the Alzheimer’s Game-Changer? A new study published in Nature suggests that lithium levels in the brain may be a critical, early factor in Alzheimer’s disease — and that restoring lithium could reverse some of the damage.  Here’s what they found: • Lithium naturally exists in the brain, and in Alzheimer’s or mild cognitive impairment cases, it’s significantly depleted.  • One reason: amyloid-β plaques (hallmarks of Alzheimer’s) seem to bind or “trap” lithium, pulling it away from he