Meiotic recombination assures genetic variation during breeding. During meiotic prophase I, chromosomes are organized in a loop-base array by a proteinaceous structure called meiotic chromosome axis ...

Meiosis is a specialised form of cell division that produces haploid gametes from diploid progenitor cells, ensuring the maintenance of chromosome number across generations. Central to this process is ...

Pairing, synapsis, and recombination are prerequisites for accurate chromosome segregation in meiosis. The phs1 gene in maize is required for pairing to occur between homologous chromosomes. In the ...

PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9 ...

Researchers have provided the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome is a rare genetic disorder characterized by stunted growth, cancer ...

Spo11-oligo mapping — Upper: the Spo11-oligo map agrees with ssDNA microarray analysis (Buhler et al., PLoS Biology, 2007) but is higher resolution. Lower: Agreement of the Spo11-oligo map with direct ...

In females, meiosis is initiated during fetal development. Digital micrographs of fetal ovary at embryonic day 14.5 hybridized to the antisense Spo11 probe are shown here in panels a and b. — Dark ...

One observation, made more than 80 years ago about precisely where on chromosomes crossovers happen, has fueled research in Dr. Gerry Smith’s laboratory in the Basic Sciences Division. That ...